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Expression and
Function of Surface Proteins in Trypanosoma Brucei
(Universitaire
Stichting 26-27
mei 1997)
Programme
Monday, May 26, 1997
Introductory words
08:30 : Baron Jacques Groothaert,
President of the Francqui Foundation
08.45 : Professor Etienne Pays, Université Libre de
Bruxelles, Brussels, Belgium
Morning session : Antigenic variation
Chairman : Professor N. Van Meirvenne,
Instituut voor Tropische Geneeskunde « Prins Leopod »,
Antwerp, Belgium
09.00-09.45 : Professor Pieter Overath,
Max-Planck-Institut für Biologie, Tübingen, Germany
Trypanosome phylogeny
and the origin of antigenic variation
09.45-10.30 :
Professor John Doneslon, University of Iowa
and Howard Hugues Medical Institute,
Iowa City, USA -
Multiple mechanisms of immune evasion by African trypanosomes
10.30-11.00 : Coffee Break
11.00-11:45 : Professor Piet Borst,
The Netherlands Cancer
Institute,
Amsterdam -
Control of VSG expression sites ; the role of the unusual base J.
11.45-12.30 : Professor Georges Cross,
The Rockefeller
University,
New
York, USA -
Regulation of VSG expression site transcription and
switching
12.30-14.00 : Lunch
Afternoon session : Controls of gene expression
Chairman : Professor D. Le Ray,
Instituut voor
Tropische Geneeskunde « Prins Leopold »,
Antwerp,
Belgium
14.00-14.45 : Professor David J. Barry,
University of
Glasgow - The Anderson College, Glasgow, UK -
Expression of
metacyclic VSG genes in Trypanosoma brucei
14.45-15.30 : Professor Luc Vanhamme,
Université
Libre de Bruxelles, Brussels, Belgium -
Genetic controls of VSG
gene expression
15.30-15.45 : Professor Magali Berberof,
Université
Libre de Bruxelles, Brussels, Belgium -
The procyclin
terminator
15.45-16.15 : Coffee Break
16.15-17.00 : Professor Isabel Roditi,
Institut
für Allgemeine Mikrobiologie, Bern, Switzerland -
Unravelling the
procyclin coat
17.00-17.45 : Professor Christine Clayton,
Universität
Heidelberg, Germany -
PARP gene expression : control at many levels
18.00 : Cocktail
*
* *
Tuesday, May 27, 1997
Morning session : Anchoring and trafficking of
surface molecules
Chairman : Professor L. Cardoso de Almaida,
Brussels and Săo Polo
08.30-09.15 :
Professor Michael Ferguson,
University of Dundee,
Scotland, UK
-
The structure and biosynthesis of GPI membrane anchors in trypanosomes
09.15-10.00 : Professor Paul Englund,
Johns Hopkins
University,
Baltimore, USA -Trypanosomes
and myristate
10.10-10.45 : Professor Mark Carrington,
University of
Cambridge, UK -
The function of the GPI-PLC
10.45-11.15 : Coffee Break
11.15-12.00 : Professor Paul Voorheis,
University of Dublin, Ireland -
The short-term
defences of Trypanosoma brucei against host antibodies
12.00-12.45 : Professor Théo Baltz,
Université de
Bordeaux II, France -
Glucose transporters in trypanosomes and glycolytic
enzymes as targets for trypanocidal drugs
12.45-14.00 : Lunch
Afternoon session : Workshop
Chairman :
Professor Etienne Pays, Université Libre de Bruxelles,
Brussels, Belgium
14.00-14.15 : Professor Gloria Rudenko,
The
Netherlands Cancer Institute,
Amsterdam
-
Switching between VSG expression sites
14.15-14.30 : Professor Miguel Navarro,
The Rockefeller
University,
New York,
USA -
Chromatin structure analysis of VSG expression site
14.30-14.45 : Professor Sheila Graham,
University of Glasgow,
The Anderson College - UK -
Functional analysis of
a metacyclic VSG gene promoter
14.45-15.00 : Professor
Elizabeth
Wirtz,
The Rockefeller University,
New York,
USA -
Probing epigenetic control and regulating gene expression with T7
transcription
15.00-15-15 :Professor D. Perez-Morga,
Université Libre de
Bruxelles,
Brussels,
Belgium
Mitochondrial reactivation by a protein interacting
with pESAG8
15.15-15.30 : Professor Frédéric Bringaud,
Université de
Bordeaux II, France -
Organization of the
region containing glucose transporter genes in the genome of
trypanosomatids
15.30-15.45 : Professor Helena Webb,
University of
Cambridge, UK -
The regulation of expression of the GPI-PLC gene
15.45-16.15 : Coffee break
16.15-16.30 : Professor Etienne Pays,
Université Libre de Bruxelles, Brussels, Belgium -
A receptor as VSG, the
VSG as receptor
16.30-16.45 : Professor Stefan Magez,
Vrije
Universiteit Brussel, Belgium -
Interactions between
Trypanosoma brucei, macrophages and TNF
16.45-17.00 : Professor Iris Ansorge,
Universität Heidelberg,
Germany -
Expression and trafficking of the trypanosome transferrin receptor
17.00-17.15 : Professor Elaine Brabazon,
University of Dublin,
Ireland -
Fate of the VSG partner in VSG-Ig complexes on the
surface of Trypanosoma brucei
17.15-17.30 : Professor David Nolan,
Université
Libre de Bruxelles,
Brussels, Belgium - New invariant surface glycoproteins of
Trypanosoma brucei
17.30-17.45 : Professor Jan Van den Abbeele, Instituut
voor Tropische Geneeskunde « Prins Leopold »,
Antwerp,
Belgium - Revisiting Trypanosoma brucei development in the tsetse fly
17.45-18.00 : Concluding remarks
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